receptor

Thyrotropin receptor (TSHR), follitropin receptor (FSHR) and lutropin/chorionic gonadotropin receptor (LHCGR) belong to the glycoprotein hormone receptors (GPHRs). They are a subgroup of family A GPCRs. This database and website have been designed to function as an information source on GPHR-related topics, collating and linking data from studies on i) naturally occurring mutations and site-directed mutations, ii) structures/structural models. Our aim is to facilitate the focused investigation of GPHRs to reveal new insights into the function and malfunction of these important receptors.

SSFA-GPHR...

  • is a database for semi-quantitative Sequence- Structure- and Function- Analysis of GPHRs,
  • provides a condensed overview of available information such as mutagenesis data for GPHRs,
  • functional data are converted into unified scaled values to compare and to classify mutagenesis data from GPHR subtypes and different experimental approaches,
  • provides analyses of data by: focused extraction, comparison, projection and mapping on three-dimensional receptor structures and models.

General Aims...

  • linking functional data with structural data for GPHR investigation,
  • contribution to new hypotheses regarding molecular interactions and activation mechanisms,
  • evaluation of data availability (including lack of information) and consistency.

New features in the second database release...

  • a structure-based search for mutation data using three-dimensional structures or homology models,
  • structural morphings between basal and activated receptor conformations allow changes in amino acid interactions during activation to be traced,
  • inclusion of double and triple mutations,
  • improved handling and features for data analyses.

Citation...

If you use and publish results extracted from the SSFA database, we acknowledge for citing:

Kreuchwig A, Kleinau G, Kreuchwig F, Worth CL, Krause G. Research resource: update and extension of a glycoprotein hormone receptors web application. Mol Endocrinol. 2011 Apr;25(4):707-12. Epub 2011 Feb 3.

Kleinau G, Kreuchwig A, Worth CL, Krause G. An interactive web-tool for molecular analyses links naturally occurring mutation data with three-dimensional structures of the rhodopsin-like glycoprotein hormone receptors. Hum Mutat. 2010 Jun;31(6):E1519-25.

Kleinau G, Brehm M, Wiedemann U, Labudde D, Leser U, Krause G. Implications for molecular mechanisms of glycoprotein hormone receptors using a new Sequence-Structure-Function Analysis resource. Mol Endocrinol. 2007 Feb;21(2):574-8