Thyrotropin receptor (TSHR), follitropin receptor (FSHR) and lutropin/chorionic gonadotropin receptor (LHCGR) belong to the glycoprotein hormone receptors (GPHRs). They are a subgroup of family A GPCRs. This database and website have been designed to function as an information source on GPHR-related topics, collating and linking data from studies on i) naturally occurring mutations and site-directed mutations, ii) structures/structural models. Our aim is to facilitate the focused investigation of GPHRs to reveal new insights into the function and malfunction of these important receptors.
- is a database for semi-quantitative Sequence- Structure- and Function- Analysis of GPHRs,
- provides a condensed overview of available information such as mutagenesis data for GPHRs,
- functional data are converted into unified scaled values to compare and to classify mutagenesis data from GPHR subtypes and different experimental approaches,
- provides analyses of data by: focused extraction, comparison, projection and mapping on three-dimensional receptor structures and models.
- linking functional data with structural data for GPHR investigation,
- contribution to new hypotheses regarding molecular interactions and activation mechanisms,
- evaluation of data availability (including lack of information) and consistency.
New features in the second database release...
- a structure-based search for mutation data using three-dimensional structures or homology models,
- structural morphings between basal and activated receptor conformations allow changes in amino acid interactions during activation to be traced,
- inclusion of double and triple mutations,
- improved handling and features for data analyses.
- Analyze contacts & interactions between hormone and receptor. Try out our new Interface Analysis Tool (at the example of hTSHR with bTSH)
If you use and publish results extracted from the SSFA database, we acknowledge for citing:
Kreuchwig A, Kleinau G, Kreuchwig F, Worth CL, Krause G. Research resource: update and extension of a glycoprotein hormone receptors web application. Mol Endocrinol. 2011 Apr;25(4):707-12. Epub 2011 Feb 3.Kleinau G, Kreuchwig A, Worth CL, Krause G. An interactive web-tool for molecular analyses links naturally occurring mutation data with three-dimensional structures of the rhodopsin-like glycoprotein hormone receptors. Hum Mutat. 2010 Jun;31(6):E1519-25.
Kleinau G, Brehm M, Wiedemann U, Labudde D, Leser U, Krause G. Implications for molecular mechanisms of glycoprotein hormone receptors using a new Sequence-Structure-Function Analysis resource. Mol Endocrinol. 2007 Feb;21(2):574-8