Results for Point Mutation
Search for mutation:
- by receptor: hTSHR
- at position: 403
Highlight result values
| Functional parameter | in red below [%] | in green above [%] |
|---|
Results
| Substructure | No | Ba-We | wildtype | mutant | binding | expression | Gs_basal activation | Gs_max stimulation | Gq_basal activation | Gq_max stimulation | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cysteine-box-3 | 403 | Asp | Ala | details | 35 | 27 | 47 | 36 | 138 | 7 | |
| Cysteine-box-3 | 403 | Asp | Glu | details | 60 | 58 | 410 | 103 | - | - | |
| Cysteine-box-3 | 403 | Asp | Lys | details | 12 | 12 | 90 | 22 | 114 | 6 | |
| Cysteine-box-3 | 403 | Asp | Leu | details | 19 | 15 | 670 | 69 | - | - | |
| Cysteine-box-3 | 403 | Asp | Asn | details | 96 | 79 | 140 | 127 | - | - | |
| Cysteine-box-3 | 403 | Asp | Asn | details | - | - | - | 25 | - | - | |
| Cysteine-box-3 | 403 | Asp | Ser | details | 82 | 82 | 130 | 112 | - | - |