Glycoprotein Hormone Receptors - TSHR, FSHR, LHCGR (LHR)

last updated: 2013-03-22

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Results for Point Mutation

Search for mutation:

by receptor: hTSHR

at position: 509

Highlight result values

Functional parameter	in red below [%]	in green above [%]
Gs_basal activation
Gs_max stimulation

Results

hTSHR

UniProtKB/Swiss-Prot

3d model

3d morph

Substructure	No	Ba-We	wildtype	mutant		Gs_basal activation	Gs_max stimulation
TMH3	509	3.40	Val	Ala	details	300	-
TMH3	509	3.40	Val	Ala	details	300	-
TMH3	509	3.40	Val	Ala	details	300	100

Parameter	Celltype	Ligand	Value [% wt]	Comment	Publication
Gs_basal activation	HEK 293		300		Karges B, Krause G, ...
Gs_max stimulation	HEK 293		100		Karges B, Krause G, ...

Sequence-Structure-Function-Analysis

Results for Point Mutation

Highlight result values

Results

Mutation details

Details for hTSHR at position 509 mutation Ala

Corresponding Mutations of homologous receptors

Mutation details

Details for hTSHR at position 509 mutation Ala

Corresponding Mutations of homologous receptors

Mutation details

Details for hTSHR at position 509 mutation Ala

Corresponding Mutations of homologous receptors