Glycoprotein Hormone Receptors - TSHR, FSHR, LHCGR (LHR)

last updated: 2013-03-22

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Results for Point Mutation

Search for mutation:

by receptor: hLHCGR

at position: 476

Highlight result values

Functional parameter	in red below [%]	in green above [%]
binding
Gs_basal activation
Gs_max stimulation

Results

hLHCGR

UniProtKB/Swiss-Prot

3d model

3d morph

Substructure	No	Ba-We	wildtype	mutant		binding	Gs_basal activation	Gs_max stimulation
ICL2	476		Gln	Ala	details	92	-	90
ICL2	476		Gln	Arg	details	-	200	100

Parameter	Celltype	Ligand	Value [% wt]	Comment	Publication
binding	HEK 293	humCG	92		Angelova K, Fanelli ...
Gs_max stimulation	HEK 293	humCG	90		Angelova K, Fanelli ...

Parameter	Celltype	Ligand	Value [% wt]	Comment	Publication
Gs_basal activation	HEK293		200	results as diagram	Feng X, Mueller T, M...
Gs_max stimulation	HEK293	humCG	100	results as diagram	Feng X, Mueller T, M...

Sequence-Structure-Function-Analysis

Results for Point Mutation

Highlight result values

Results

Mutation details

Details for hLHCGR at position 476 mutation Ala

Corresponding Mutations of homologous receptors

Mutation details

Details for hLHCGR at position 476 mutation Arg

Corresponding Mutations of homologous receptors