Glycoprotein Hormone Receptors - TSHR, FSHR, LHCGR (LHR)
Sequence-Structure-Function-Analysis
of Glycoprotein Hormone Receptors
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last updated: 2013-03-22
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Results for Point Mutation
Search for mutation:
by receptor: rLHCGR
at position: 209
Highlight result values
Functional parameter
in red below [%]
in green above [%]
binding
Update
Gs_max stimulation
Update
Results
rLHCGR
UniProtKB/Swiss-Prot
3d model
Substructure
No
Ba-We
wildtype
mutant
binding
Gs_max stimulation
LRR8
209
Lys
Glu
details
1
4
LRR8
209
Lys
Gly
details
28
76
LRR8
209
Lys
Gln
details
92
98
LRR8
209
Lys
Arg
details
72
90
Mutation details
Details for rLHCGR at position 209 mutation Glu
Parameter
Celltype
Ligand
Value [% wt]
Comment
Publication
binding
COS-7
humCG
1
Bhowmick N, Narayan ...
Gs_max stimulation
COS-7
humCG
4
Bhowmick N, Narayan ...
Corresponding Mutations of homologous receptors
Receptor
Wildtype
Position
Ba-We
hTSHR
Asn
208
details
rFSHR
Ser
201
details
Mutation details
Details for rLHCGR at position 209 mutation Gly
Parameter
Celltype
Ligand
Value [% wt]
Comment
Publication
binding
COS-7
humCG
28
Bhowmick N, Narayan ...
Gs_max stimulation
COS-7
humCG
76
Bhowmick N, Narayan ...
Corresponding Mutations of homologous receptors
Receptor
Wildtype
Position
Ba-We
hTSHR
Asn
208
details
rFSHR
Ser
201
details
Mutation details
Details for rLHCGR at position 209 mutation Gln
Parameter
Celltype
Ligand
Value [% wt]
Comment
Publication
binding
COS-7
humCG
92
Bhowmick N, Narayan ...
Gs_max stimulation
COS-7
humCG
98
Bhowmick N, Narayan ...
Corresponding Mutations of homologous receptors
Receptor
Wildtype
Position
Ba-We
hTSHR
Asn
208
details
rFSHR
Ser
201
details
Mutation details
Details for rLHCGR at position 209 mutation Arg
Parameter
Celltype
Ligand
Value [% wt]
Comment
Publication
binding
COS-7
humCG
72
Bhowmick N, Narayan ...
Gs_max stimulation
COS-7
humCG
90
Bhowmick N, Narayan ...
Corresponding Mutations of homologous receptors
Receptor
Wildtype
Position
Ba-We
hTSHR
Asn
208
details
rFSHR
Ser
201
details
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first release: 2005-08-25
Results for Point Mutation