Glycoprotein Hormone Receptors - TSHR, FSHR, LHCGR (LHR)

last updated: 2013-03-22

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Results for Point Mutation

Search for mutation:

by receptor: rLHCGR

at position: 359

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Functional parameter	in red below [%]	in green above [%]
binding
expression
Gs_max stimulation

Results

rLHCGR

UniProtKB/Swiss-Prot

3d model

3d morph

Substructure	No	wildtype	mutant		binding	expression	Gs_max stimulation
TMH1	359	Asp	Ala	details	22	-	12
TMH1	359	Asp	Glu	details	39	-	25
TMH1	359	Asp	Lys	details	-	9	-

Parameter	Celltype	Ligand	Value [% wt]	Comment	Publication
binding	COS-7	humCG	22		Alvarez CA, Narayan ...
Gs_max stimulation	COS-7	humCG	12		Alvarez CA, Narayan ...

Parameter	Celltype	Ligand	Value [% wt]	Comment	Publication
binding	COS-7	humCG	39		Alvarez CA, Narayan ...
Gs_max stimulation	COS-7	humCG	25		Alvarez CA, Narayan ...

Sequence-Structure-Function-Analysis

Results for Point Mutation

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Results

Mutation details

Details for rLHCGR at position 359 mutation Ala

Corresponding Mutations of homologous receptors

Mutation details

Details for rLHCGR at position 359 mutation Glu

Corresponding Mutations of homologous receptors

Mutation details

Details for rLHCGR at position 359 mutation Lys

Corresponding Mutations of homologous receptors