AF6/ERBIN/SNA1 PDZ domain - Selectivity below 100 micro-molar

Recognized by the AF6, ERBIN and SNA1 PDZ domains

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P3 P2 P1 P0 Seq. AF6-Kd ERBIN-Kd SNA1-Kd
G T F V GTFV 9.22 71.09 91.78
A T F V ATFV 9.95 75.83 47.76
E I W V EIWV 10.33 30.52 76.51
G T W V GTWV 10.36 33.97 51.65
A T W V ATWV 11.18 36.23 26.88
E T F V ETFV 12.17 13.93 18.70
E V W V EVWV 13.43 20.80 72.70
E F W V EFWV 13.51 56.62 93.24
E T W V ETWV 13.66 6.66 10.52
P T W V PTWV 15.62 60.29 91.06
E L W V ELWV 15.82 73.46 99.36
S T F V STFV 17.35 56.91 36.18
G S W V GSWV 18.11 64.78 50.13
S T W V STWV 19.48 27.19 20.36
A S W V ASWV 19.55 69.09 26.09
E S F V ESFV 21.28 26.57 18.15
E T Y V ETYV 21.64 32.15 12.61
E T L V ETLV 23.41 69.99 16.15
E S W V ESWV 23.89 12.70 10.21
E T F I ETFI 27.89 62.24 29.08
E I W L EIWL 28.38 77.84 97.07
G T W L GTWL 28.45 86.65 65.54
A T W L ATWL 30.71 92.42 34.10
E T W I ETWI 31.32 29.74 16.37
W T F V WTFV 32.10 82.17 86.84
D T F V DTFV 32.25 26.12 54.37
Q T F V QTFV 33.31 76.91 36.81
E T F L ETFL 33.43 35.55 23.73
S S W V SSWV 34.07 51.85 19.76
W T W V WTWV 36.04 39.26 48.87
D T W V DTWV 36.22 12.48 30.60
E V W L EVWL 36.91 53.05 92.25
V T F V VTFV 37.08 58.41 35.02
H T F V HTFV 37.23 80.65 39.87
T T F V TTFV 37.39 65.45 57.74
Q T W V QTWV 37.40 36.75 20.71
E T W L ETWL 37.54 16.98 13.35
E S Y V ESYV 37.85 61.31 12.24
E T W F ETWF 41.23 90.38 38.87
V T W V VTWV 41.63 27.91 19.71
H T W V HTWV 41.81 38.53 22.44
T T W V TTWV 41.98 31.27 32.50
F T F V FTFV 42.58 76.78 54.20
E T T V ETTV 42.75 61.50 6.13
I T F V ITFV 46.62 68.07 59.61
N T F V NTFV 47.58 94.03 51.27
F T W V FTWV 47.81 36.68 30.50
Y T W V YTWV 48.88 54.75 46.04
E I D V EIDV 49.71 88.66 73.65
G T D V GTDV 49.83 98.69 49.72
E A W V EAWV 50.09 47.64 70.63
I T W V ITWV 52.36 32.52 33.55
E H W V EHWV 52.48 68.18 89.27
N T W V NTWV 53.43 44.93 28.86
S T W L STWL 53.53 69.36 25.83
E Q W V EQWV 54.70 58.91 80.13
E S W I ESWI 54.76 56.71 15.89
D S F V DSFV 56.40 49.81 52.77
E V N V EVNV 56.83 90.23 61.05
M T F V MTFV 56.93 90.22 42.29
D T Y V DTYV 57.37 60.26 36.66
E T N V ETNV 57.80 28.89 8.84
E S F L ESFL 58.46 67.79 23.03
E T E V ETEV 59.45 45.09 8.79
E T Y L ETYL 59.47 82.01 16.00
E V S V EVSV 62.30 77.74 65.01
E T Q V ETQV 62.60 33.81 9.78
W S W V WSWV 63.03 74.87 47.43
D S W V DSWV 63.34 23.80 29.70
E T S V ETSV 63.37 24.89 9.41
M T W V MTWV 63.93 43.11 23.80
L T W V LTWV 64.57 55.52 37.02
E V D V EVDV 64.64 60.42 69.98
Q S W V QSWV 65.40 70.08 20.10
E S W L ESWL 65.65 32.39 12.96
E T D V ETDV 65.75 19.34 10.13
R T W V RTWV 65.95 63.58 34.12
E R W V ERWV 66.25 73.54 84.36
E K W V EKWV 69.62 78.10 78.21
E T M V ETMV 70.02 42.52 11.79
K T W V KTWV 70.41 72.01 39.02
V S W V VSWV 72.81 53.22 19.13
H S W V HSWV 73.11 73.48 21.78
T S W V TSWV 73.42 59.63 31.54
E E W V EEWV 76.83 50.84 65.29
E N W V ENWV 77.36 73.14 77.07
E G W V EGWV 77.80 77.50 96.96
E T H V ETHV 79.87 39.20 11.76
E T R V ETRV 80.49 34.19 7.30
E I A V EIAV 82.18 94.10 59.51
D T W I DTWI 83.02 55.74 47.59
F S W V FSWV 83.61 69.96 29.60
D T F L DTFL 88.62 66.62 68.98
E D W V EDWV 89.77 63.58 72.87
I S W V ISWV 91.56 62.03 32.56
E T W T ETWT 92.32 81.00 47.53
N S W V NSWV 93.43 85.68 28.01
S T D V STDV 93.76 79.00 19.60
E T P V ETPV 96.06 36.10 16.40
E P W V EPWV 97.08 84.84 97.77
D T W L DTWL 99.52 31.83 38.82

Reference:
Urs Wiedemann and Prisca Boisguerin, Rainer Leben, Dietmar Leitner, Gerd Krause, Karin Moelling, Rudolf Volkmer-Engert and Hartmut Oschkinat (2004) submitted.


Last modified: Sun May 02 19:09:10 W. Europe Daylight Time 2004

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