AF6/ERBIN/SNA1 PDZ domain - Selectivity below 50 micro-molar

Recognized by the AF6, ERBIN and SNA1 PDZ domains

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P3 P2 P1 P0 Seq. AF6-Kd ERBIN-Kd SNA1-Kd
A T W V ATWV 11.18 36.23 26.88
E T F V ETFV 12.17 13.93 18.70
E T W V ETWV 13.66 6.66 10.52
S T W V STWV 19.48 27.19 20.36
E S F V ESFV 21.28 26.57 18.15
E T Y V ETYV 21.64 32.15 12.61
E S W V ESWV 23.89 12.70 10.21
E T W I ETWI 31.32 29.74 16.37
E T F L ETFL 33.43 35.55 23.73
W T W V WTWV 36.04 39.26 48.87
D T W V DTWV 36.22 12.48 30.60
Q T W V QTWV 37.40 36.75 20.71
E T W L ETWL 37.54 16.98 13.35
V T W V VTWV 41.63 27.91 19.71
H T W V HTWV 41.81 38.53 22.44
T T W V TTWV 41.98 31.27 32.50
F T W V FTWV 47.81 36.68 30.50

Reference:
Urs Wiedemann and Prisca Boisguerin, Rainer Leben, Dietmar Leitner, Gerd Krause, Karin Moelling, Rudolf Volkmer-Engert and Hartmut Oschkinat (2004) submitted.


Last modified: Sun May 02 19:08:13 W. Europe Daylight Time 2004

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