AF6/SNA1 PDZ domain - Selectivity below 100 micro-molar

Recognized by the AF6 and SNA1 PDZ domains

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P3 P2 P1 P0 Seq. AF6-Kd ERBIN-Kd SNA1-Kd
G S F V GSFV 16.13 135.57 89.08
E I Y V EIYV 16.36 147.36 91.66
G T Y V GTYV 16.40 164.02 61.88
A S F V ASFV 17.41 144.61 46.36
A T Y V ATYV 17.71 174.95 32.20
G T L V GTLV 17.75 357.05 79.28
A T L V ATLV 19.15 380.85 41.26
E V Y V EVYV 21.28 100.42 87.10
A T F I ATFI 22.82 338.69 74.28
G T W I GTWI 23.74 151.71 80.33
A T W I ATWI 25.62 161.82 41.80
E I I V EIIV 26.46 702.31 64.84
G T I V GTIV 26.52 781.72 43.78
E I V V EIVV 27.21 556.81 47.41
G T V V GTVV 27.27 619.77 32.01
P S W V PSWV 27.31 114.97 88.38
A T F L ATFL 27.35 193.43 60.60
A T I V ATIV 28.63 833.82 22.78
G S Y V GSYV 28.68 312.79 60.06
A T V V ATVV 29.44 661.08 16.66
S S F V SSFV 30.34 108.52 35.11
S T Y V STYV 30.86 131.29 24.39
A S Y V ASYV 30.96 333.64 31.26
G S L V GSLV 31.03 680.91 76.95
E I T V EITV 32.32 281.89 44.57
G T T V GTTV 32.40 313.76 30.09
S T L V STLV 33.39 285.81 31.25
A S L V ASLV 33.50 726.30 40.04
A T W F ATWF 33.73 491.84 99.27
E V I V EVIV 34.40 478.59 61.62
E F I V EFIV 34.60 1303.06 79.02
A T T V ATTV 34.97 334.67 15.66
E T I V ETIV 34.99 153.23 8.92
E V V V EVVV 35.38 379.45 45.05
E F V V EFVV 35.59 1033.11 57.78
E T V V ETVV 35.99 121.48 6.52
E T F F ETFF 36.72 189.17 69.06
G T Y I GTYI 37.60 732.59 96.24
S I V V SIVV 38.80 2273.86 91.72
S T F I STFI 39.77 254.17 56.26
A S F I ASFI 39.90 645.89 72.09
P T I V PTIV 39.99 1387.49 77.17
E L I V ELIV 40.52 1690.68 84.21
A T Y I ATYI 40.58 781.41 50.08
E S L V ESLV 40.94 133.47 15.68
P T V V PTVV 41.13 1100.05 56.42
G S W I GSWI 41.51 289.32 77.97
E L V V ELVV 41.67 1340.43 61.57
E V T V EVTV 42.03 192.10 42.36
E F T V EFTV 42.27 523.01 54.32
Y T F V YTFV 43.53 114.60 81.81
E I N V EINV 43.70 132.40 64.25
G T N V GTNV 43.81 147.38 43.37
A T L I ATLI 43.90 1701.06 64.16
S T W I STWI 44.66 121.44 31.66
A S W I ASWI 44.80 308.60 40.57
E I E V EIEV 44.95 206.66 63.90
G T E V GTEV 45.06 230.02 43.14
G T Y L GTYL 45.07 418.39 78.52
S I T V SITV 46.09 1151.15 86.24
G S I V GSIV 46.38 1490.77 42.49
A T N V ATNV 47.29 157.20 22.57
E I Q V EIQV 47.33 154.95 71.09
G T Q V GTQV 47.45 172.47 48.00
S T F L STFL 47.67 145.16 45.90
G S V V GSVV 47.70 1181.93 31.06
A S F L ASFL 47.83 368.88 58.82
E I S V EISV 47.91 114.09 68.42
G T S V GTSV 48.03 126.99 46.19
A T E V ATEV 48.63 245.35 22.45
A T Y L ATYL 48.65 446.28 40.86
E S F I ESFI 48.77 118.69 28.23
P T T V PTTV 48.86 556.90 53.05
E L T V ELTV 49.50 678.59 57.89
E T Y I ETYI 49.61 143.60 19.61
G S W L GSWL 49.76 165.24 63.61
S T I V STIV 49.90 625.73 17.26
A S I V ASIV 50.06 1590.13 22.11
E W V V EWVV 50.09 1442.62 73.40
S V V V SVVV 50.45 1549.54 87.16
A T Q V ATQV 51.21 183.96 24.98
S T V V STVV 51.32 496.10 12.62
A S V V ASVV 51.48 1260.71 16.17
A T S V ATSV 51.84 135.45 24.04
A T L L ATLL 52.63 971.50 52.35
E I M V EIMV 52.94 194.90 85.72
G T M V GTMV 53.07 216.93 57.87
E T L I ETLI 53.66 312.59 25.12
A S W L ASWL 53.71 176.25 33.10
A T D V ATDV 53.79 105.27 25.87
S S Y V SSYV 53.97 250.38 23.68
W S F V WSFV 56.13 156.70 84.28
G S T V GSTV 56.66 598.35 29.21
W T Y V WTYV 57.09 189.58 58.55
E F N V EFNV 57.16 245.66 78.30
A T M V ATMV 57.28 231.39 30.12
L T F V LTFV 57.50 116.21 65.77
Q S F V QSFV 58.24 146.68 35.72
S S L V SSLV 58.39 545.04 30.33
E V E V EVEV 58.45 140.83 60.72
R T F V RTFV 58.73 133.06 60.63
E F E V EFEV 58.79 383.43 77.88
S T W F STWF 58.80 369.10 75.20
A S W F ASWF 58.99 937.97 96.35
Q T Y V QTYV 59.24 177.45 24.82
E W T V EWTV 59.51 730.33 69.01
S V T V SVTV 59.93 784.46 81.95
E I H V EIHV 60.38 179.65 85.46
G T H V GTHV 60.53 199.97 57.69
G T I I GTII 60.79 3491.51 68.08
E I R V EIRV 60.85 156.69 53.07
S T T V STTV 60.96 251.15 11.86
G T R V GTRV 61.00 174.41 35.83
A S T V ASTV 61.16 638.24 15.20
E S I V ESIV 61.19 292.21 8.66
E V Q V EVQV 61.55 105.59 67.56
W T L V WTLV 61.76 412.70 75.01
E F Q V EFQV 61.90 287.48 86.64
D T L V DTLV 62.06 131.18 46.97
E I V I EIVI 62.36 2486.99 73.73
G T V I GTVI 62.52 2768.19 49.78
E F S V EFSV 62.66 211.67 83.38
K T F V KTFV 62.70 150.71 69.33
E S V V ESVV 62.93 231.67 6.33
Q T L V QTLV 64.09 386.29 31.79
E S F F ESFF 64.21 360.75 67.03
E T L L ETLL 64.33 178.53 20.50
V S F V VSFV 64.84 111.39 33.99
E F D V EFDV 65.02 164.51 89.76
H S F V HSFV 65.10 153.80 38.70
E T Y F ETYF 65.31 436.45 46.57
A T H V ATHV 65.34 213.30 30.02
T S F V TSFV 65.38 124.81 56.04
A T I I ATII 65.61 3724.23 35.43
G S Y I GSYI 65.75 1397.07 93.41
A T R V ATRV 65.85 186.04 18.65
V T Y V VTYV 65.95 134.77 23.61
P T N V PTNV 66.06 261.58 76.46
H T Y V HTYV 66.22 186.07 26.88
T T Y V TTYV 66.50 150.99 38.93
E L N V ELNV 66.93 318.74 83.43
A T V I ATVI 67.48 2952.69 25.90
P T E V PTEV 67.95 408.27 76.05
E V M V EVMV 68.84 132.81 81.46
E L E V ELEV 68.84 497.48 82.99
S S F I SSFI 69.55 484.70 54.61
P S I V PSIV 69.94 2646.00 74.90
E T L F ETLF 70.66 950.10 59.66
S T Y I STYI 70.74 586.41 37.94
A S Y I ASYI 70.97 1490.19 48.61
V T L V VTLV 71.35 293.37 30.25
P T Q V PTQV 71.55 306.11 84.61
H T L V HTLV 71.64 405.04 34.44
P S V V PSVV 71.93 2097.83 54.76
T T L V TTLV 71.94 328.70 49.88
E S W F ESWF 72.11 172.37 37.72
P T S V PTSV 72.42 225.39 81.43
E L Q V ELQV 72.49 373.00 92.33
E I I L EIIL 72.69 1791.51 82.27
G T P V GTPV 72.81 184.16 80.50
G T I L GTIL 72.87 1994.07 55.54
E L S V ELSV 73.38 274.64 88.85
D T F I DTFI 73.93 116.66 84.55
E I T I EITI 74.08 1259.04 69.32
G T T I GTTI 74.26 1401.40 46.80
F S F V FSFV 74.46 146.42 52.60
Q I V V QIVV 74.48 3073.32 93.31
E S T V ESTV 74.75 117.29 5.95
E I V L EIVL 74.76 1420.37 60.15
G T V L GTVL 74.94 1580.96 40.61
P T D V PTDV 75.15 175.16 87.65
F T Y V FTYV 75.74 177.14 36.54
Y S F V YSFV 76.12 218.54 79.40
E L D V ELDV 76.14 213.44 95.64
Q T F I QTFI 76.34 343.53 57.24
S T L I STLI 76.53 1276.54 48.60
G S N V GSNV 76.61 281.05 42.10
A S L I ASLI 76.78 3243.98 62.28
Y T Y V YTYV 77.42 264.39 55.16
S S W I SSWI 78.10 231.59 30.73
E V H V EVHV 78.52 122.43 81.21
A T P V ATPV 78.59 196.43 41.89
A T I L ATIL 78.66 2126.98 28.90
G S E V GSEV 78.79 438.66 41.87
G S Y L GSYL 78.82 797.89 76.21
E V I I EVII 78.85 2137.62 95.83
E V R V EVRV 79.13 106.78 50.43
E A Y V EAYV 79.35 230.05 84.63
E F R V EFRV 79.59 290.73 64.68
A T T I ATTI 80.16 1494.81 24.36
E T I I ETII 80.20 684.38 13.87
E W N V EWNV 80.46 343.04 99.46
A T V L ATVL 80.89 1686.34 21.13
E V V I EVVI 81.09 1694.78 70.06
I S F V ISFV 81.53 129.82 57.86
E F V I EFVI 81.57 4614.32 89.85
F T L V FTLV 81.93 385.61 46.82
E T F T ETFT 82.22 169.52 84.45
G T A V GTAV 82.39 104.74 40.18
S T N V STNV 82.42 117.97 17.10
E T V I ETVI 82.48 542.60 10.14
W T W I WTWI 82.61 175.36 76.00
A S N V ASNV 82.69 299.78 21.91
E W E V EWEV 82.75 535.41 98.93
V I V V VIVV 82.91 2334.04 88.78
I T Y V ITYV 82.93 157.06 40.20
G S Q V GSQV 82.97 328.90 46.59
N S F V NSFV 83.21 179.33 49.76
S S F L SSFL 83.37 276.82 44.55
Y T L V YTLV 83.76 575.55 70.67
G S S V GSSV 83.99 242.17 44.83
N T Y V NTYV 84.63 216.95 34.57
S T E V STEV 84.77 184.12 17.01
S T Y L STYL 84.80 334.91 30.95
V T F I VTFI 84.98 260.89 54.46
A S E V ASEV 85.05 467.90 21.79
A S Y L ASYL 85.08 851.07 39.66
G S L L GSLL 85.27 1736.93 97.63
H T F I HTFI 85.33 360.20 62.00
P S T V PSTV 85.44 1062.03 51.49
Y S W V YSWV 85.47 104.42 44.69
T T F I TTFI 85.69 292.31 89.80
Q T W I QTWI 85.73 164.14 32.21
A T I F ATIF 86.39 11319.38 84.13
E Q Y V EQYV 86.64 284.47 96.00
E S Y I ESYI 86.75 273.85 19.03
G S D V GSDV 87.15 188.20 48.26
S S I V SSIV 87.26 1193.30 16.75
Q I T V QITV 88.47 1555.87 87.73
E I T L EITL 88.80 719.06 56.56
A T V F ATVF 88.85 8974.38 61.51
A T A V ATAV 88.93 111.72 20.91
G T T L GTTL 89.02 800.37 38.18
S T Q V STQV 89.27 138.05 18.92
A S Q V ASQV 89.56 350.82 24.24
I T L V ITLV 89.72 341.89 51.50
S S V V SSVV 89.74 946.09 12.25
S T S V STSV 90.36 101.65 18.21
A S S V ASSV 90.66 258.31 23.33
Q T F L QTFL 91.51 196.19 46.70
N T L V NTLV 91.56 472.29 44.29
S T L L STLL 91.74 729.06 39.65
P T R V PTRV 92.00 309.56 63.16
A S L L ASLL 92.04 1852.70 50.81
W T I V WTIV 92.30 903.55 41.42
E T F A ETFA 92.42 180.49 83.23
D T I V DTIV 92.76 287.20 25.93
G S M V GSMV 92.80 413.70 56.17
S T Y F STYF 93.14 1782.31 90.09
E L R V ELRV 93.20 377.21 68.92
S S W L SSWL 93.62 132.27 25.07
E S L I ESLI 93.85 596.13 24.38
A S D V ASDV 94.07 200.75 25.11
P T V I PTVI 94.28 4913.31 87.75
E V I L EVIL 94.52 1220.84 78.18
W T V V WTVV 94.93 716.36 30.28
D T V V DTVV 95.39 227.70 18.96
V T W I VTWI 95.43 124.65 30.65
E L V I ELVI 95.51 5986.96 95.75
Q T I V QTIV 95.78 845.73 17.56
H T W I HTWI 95.82 172.10 34.90
A T T L ATTL 96.09 853.71 19.87
E T I L ETIL 96.14 390.86 11.32
T T W I TTWI 96.23 139.66 50.54
E V T I EVTI 96.33 857.98 65.88
Q V V V QVVV 96.85 2094.34 88.67
E F T I EFTI 96.89 2336.01 84.48
E V V L EVVL 97.21 967.92 57.16
F T F I FTFI 97.59 342.92 84.28
E F V L EFVL 97.78 2635.33 73.31
E T T I ETTI 97.98 274.69 9.54
V I T V VITV 98.49 1181.61 83.48
Q T V V QTVV 98.51 670.53 12.84
E T V L ETVL 98.88 309.89 8.27
H I T V HITV 98.89 1631.40 95.04
W T W L WTWL 99.03 100.15 62.01
M S F V MSFV 99.55 172.05 41.04
W S Y V WSYV 99.84 361.54 56.83
S T M V STMV 99.84 173.65 22.81

Reference:
Urs Wiedemann and Prisca Boisguerin, Rainer Leben, Dietmar Leitner, Gerd Krause, Karin Moelling, Rudolf Volkmer-Engert and Hartmut Oschkinat (2004) submitted.


Last modified: Sun May 02 19:12:19 W. Europe Daylight Time 2004

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