AF6/SNA1 PDZ domain - Selectivity below 50 micro-molar

Recognized by the AF6 and SNA1 PDZ domains

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P3 P2 P1 P0 Seq. AF6-Kd ERBIN-Kd SNA1-Kd
A T F V ATFV 9.95 75.83 47.76
S T F V STFV 17.35 56.91 36.18
A S F V ASFV 17.41 144.61 46.36
A T Y V ATYV 17.71 174.95 32.20
A T L V ATLV 19.15 380.85 41.26
A S W V ASWV 19.55 69.09 26.09
E T L V ETLV 23.41 69.99 16.15
A T W I ATWI 25.62 161.82 41.80
G T I V GTIV 26.52 781.72 43.78
E I V V EIVV 27.21 556.81 47.41
G T V V GTVV 27.27 619.77 32.01
E T F I ETFI 27.89 62.24 29.08
A T I V ATIV 28.63 833.82 22.78
A T V V ATVV 29.44 661.08 16.66
S S F V SSFV 30.34 108.52 35.11
A T W L ATWL 30.71 92.42 34.10
S T Y V STYV 30.86 131.29 24.39
A S Y V ASYV 30.96 333.64 31.26
E I T V EITV 32.32 281.89 44.57
G T T V GTTV 32.40 313.76 30.09
Q T F V QTFV 33.31 76.91 36.81
S T L V STLV 33.39 285.81 31.25
A S L V ASLV 33.50 726.30 40.04
S S W V SSWV 34.07 51.85 19.76
A T T V ATTV 34.97 334.67 15.66
E T I V ETIV 34.99 153.23 8.92
E V V V EVVV 35.38 379.45 45.05
E T V V ETVV 35.99 121.48 6.52
V T F V VTFV 37.08 58.41 35.02
H T F V HTFV 37.23 80.65 39.87
E S Y V ESYV 37.85 61.31 12.24
E S L V ESLV 40.94 133.47 15.68
E T W F ETWF 41.23 90.38 38.87
E V T V EVTV 42.03 192.10 42.36
E T T V ETTV 42.75 61.50 6.13
G T N V GTNV 43.81 147.38 43.37
S T W I STWI 44.66 121.44 31.66
A S W I ASWI 44.80 308.60 40.57
G T E V GTEV 45.06 230.02 43.14
G S I V GSIV 46.38 1490.77 42.49
A T N V ATNV 47.29 157.20 22.57
G T Q V GTQV 47.45 172.47 48.00
S T F L STFL 47.67 145.16 45.90
G S V V GSVV 47.70 1181.93 31.06
G T S V GTSV 48.03 126.99 46.19
A T E V ATEV 48.63 245.35 22.45
A T Y L ATYL 48.65 446.28 40.86
E S F I ESFI 48.77 118.69 28.23
Y T W V YTWV 48.88 54.75 46.04
E T Y I ETYI 49.61 143.60 19.61
G T D V GTDV 49.83 98.69 49.72
S T I V STIV 49.90 625.73 17.26

Reference:
Urs Wiedemann and Prisca Boisguerin, Rainer Leben, Dietmar Leitner, Gerd Krause, Karin Moelling, Rudolf Volkmer-Engert and Hartmut Oschkinat (2004) submitted.


Last modified: Sun May 02 19:13:02 W. Europe Daylight Time 2004

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