ERBIN/SNA1 PDZ domain - Selectivity below 100 micro-molar

Recognized by the ERBIN and SNA1 PDZ domains

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P3 P2 P1 P0 Seq. AF6-Kd ERBIN-Kd SNA1-Kd
E T A V ETAV 108.70 20.53 8.19
D T D V DTDV 174.29 36.26 29.45
E S D V ESDV 114.98 36.89 9.83
D T A V DTAV 288.15 38.48 23.80
E S A V ESAV 190.09 39.15 7.94
D T S V DTSV 167.98 46.65 27.36
E S S V ESSV 110.81 47.47 9.13
E T D L ETDL 180.66 49.34 12.85
E T A L ETAL 298.67 52.37 10.39
D T N V DTNV 153.22 54.14 25.69
E S N V ESNV 101.08 55.09 8.58
E T K V ETKV 144.81 57.23 8.76
D S W L DSWL 174.03 60.71 37.68
D T Q V DTQV 165.94 63.36 28.43
E T S L ETSL 174.11 63.49 11.94
D T R V DTRV 213.37 64.08 21.22
E V A V EVAV 106.87 64.13 56.55
E S Q V ESQV 109.47 64.47 9.49
E S R V ESRV 140.75 65.20 7.09
D T P V DTPV 254.66 67.66 47.69
E S P V ESPV 167.99 68.84 15.92
D S D V DSDV 304.80 69.14 28.59
V T W L VTWL 114.40 71.19 25.01
D S A V DSAV 503.89 73.39 23.10
D T H V DTHV 211.71 73.47 34.18
E T N L ETNL 158.81 73.69 11.21
E S H V ESHV 139.66 74.75 11.41
D T M V DTMV 185.60 79.70 34.28
T T W L TTWL 115.35 79.76 41.23
V T D V VTDV 200.36 81.09 18.97
E S M V ESMV 122.44 81.09 11.44
M S W V MSWV 111.79 82.20 23.10
I T W L ITWL 143.86 82.97 42.57
S T A V STAV 155.01 83.84 15.84
D T E V DTEV 157.59 84.51 25.56
E S E V ESEV 103.96 85.98 8.53
V T A V VTAV 331.23 86.06 15.33
E T Q L ETQL 172.00 86.23 12.41
E T W A ETWA 103.78 86.24 46.84
E T D I ETDI 150.70 86.40 15.76
E T R L ETRL 221.16 87.21 9.26
D S S V DSSV 293.75 88.97 26.56
T T D V TTDV 202.03 90.85 31.28
E T A I ETAI 249.15 91.70 12.73
E T P L ETPL 263.95 92.08 20.81
D T D L DTDL 478.90 92.49 37.37
F T W L FTWL 131.38 93.58 38.70
Q T W L QTWL 102.77 93.74 26.28
E S D L ESDL 315.92 94.10 12.48
I T D V ITDV 251.95 94.50 32.30
T T A V TTAV 334.00 96.43 25.28
E T W S ETWS 109.30 96.73 92.63
E T W R ETWR 115.70 97.01 82.87
D T A L DTAL 791.73 98.16 30.20
H T W L HTWL 114.87 98.29 28.47
E T W H ETWH 102.00 98.34 78.40
E S A L ESAL 522.29 99.88 10.08
E T W M ETWM 108.75 99.91 81.14
E T H L ETHL 219.45 99.99 14.92

Reference:
Urs Wiedemann and Prisca Boisguerin, Rainer Leben, Dietmar Leitner, Gerd Krause, Karin Moelling, Rudolf Volkmer-Engert and Hartmut Oschkinat (2004) submitted.


Last modified: Sun May 02 19:14:53 W. Europe Daylight Time 2004

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