Hormones

Fox KM, Dias JA, Van Roey P Three-dimensional structure of human follicle-stimulating hormone Mol Endocrinol. 2001 Mar;15(3):378-89 PDB: 1FL7 | Tegoni M, Spinelli S, Verhoeyen M, Davis P, Cambillau C Crystal structure of a ternary complex between human chorionic gonadotropin (hCG) and two Fv fragments specific for the alpha and beta-subunits J Mol Biol. 1999 Jun 25;289(5):1375-85 PDB: 1QFW | Lapthorn AJ, Harris DC, Littlejohn A, Lustbader JW, Canfield RE, Machin KJ, Morgan FJ, Isaacs NW Crystal structure of human chorionic gonadotropin Nature. 1994 Jun 9;369(6480):455-61 PDB: 1HRP | |
Serpentine domain (Rhodopsin)
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Standfuss, J., Xie, G., Edwards, P.C., Burghammer, M., Oprian, D.D., Schertler, G.F. Crystal Structure of a Thermally Stable Rhodopsin Mutant. J.Mol.Biol. v372 pp. 1179, 2007 PDB: 2J4Y | Salom, D., Lodowski, D.T., Stenkamp, R.E., Trong, I.L., Golczak, M., Jastrzebska, B., Harris, T., Ballesteros, J.A., Palczewski, K Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc.Natl.Acad.Sci.Usa v103 pp. 16123-16128, 2006 PDB: 2I35 | Okada T, Sugihara M, Bondar AN, Elstner M, Entel P, Buss V The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure J Mol Biol. 2004 Sep 10;342(2):571-83 PDB: 1U19 | Li J, Edwards PC, Burghammer M, Villa C, Schertler GF Structure of bovine rhodopsin in a trigonal crystal form J Mol Biol. 2004 Nov 5;343(5):1409-38 PDB: 1GZM | Teller, D.C., Okada, T., Behnke, C.A., Palczewski, K., Stenkamp, R.E. Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs). Biochemistry v40 pp. 7761-7772, 2001 PDB: 1HZX | Palczewski K, Kumasaka T, Hori T, Behnke CA, Motoshima H, Fox BA, Le Trong I, Teller DC, Okada T, Stenkamp RE, Yamamoto M, Miyano M Crystal structure of rhodopsin: A G protein-coupled receptor Science. 2000 Aug 4;289(5480):739-45 PDB: 1F88 | |
Serpentine domain (beta(2)-adrenergic receptor)
-adrenergic receptor).gif)
Rasmussen, S.G., Choi, H.J., Rosenbaum, D.M., Kobilka, T.S., Thian, F.S., Edwards, P.C., Burghammer, M., Ratnala, V.R., Sanishvili, R., Fischetti, R.F., Schertler, G.F., Weis, W.I., Kobilka, B.K. Crystal structure of the human beta(2) adrenergic G-protein-coupled receptor. Nature, 2007 PDB: 2R4R | Cherezov, V., Rosenbaum, D.M., Hanson, M.A., Rasmussen, S.G., Thian, F.S., Kobilka, T.S., Choi, H.J., Kuhn, P., Weis, W.I., Kobilka, B.K., Stevens, R.C. High-Resolution Crystal Structure of an Engineered Human {beta}2-Adrenergic G Protein Coupled Receptor. Science, 2007 PDB: 2RH1 | |
Serpentine domain (beta(1)-adrenergic receptor)
-adrenergic receptor).gif)
Warne, A., Serrano-Vega, M.J., Baker, J.G., Moukhametzianov, R., Edwards, P.C., Henderson, R., Leslie, A.G.W., Tate, C.G., Schertler, G.F.X. Structure of the Beta1-Adrenergic G Protein-Coupled Receptor (2008) Nature 454: 486 PDB: 2VT4 | |
Serpentine domain (Adenosine receptor)
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Jaakola, V.P., Griffith, M.T., Hanson, M.A., Cherezov, V., Chien, E.Y., Lane, J.R., Ijzerman, A.P., Stevens, R.C. The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist (2008) Science 322: 1211-1217 PDB: 3EML | |
Serpentine domain (Opsin)
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Scheerer, P., Park, J.H., Hildebrand, P.W., Kim, Y.J., Krauss, N., Choe, H.-W., Hofmann, K.P., Ernst, O.P. Crystal structure of opsin in its G-protein-interacting conformation (2008) Nature 455: 497-502 PDB: 3DQB | Park, J.H., Scheerer, P., Hofmann, K.P., Choe, H.-W., Ernst, O.P. Crystal structure of the ligand-free G-protein-coupled receptor opsin (2008) Nature 454: 183-187 PDB: 3CAP | |
Cysteine-box LRR FSHR LRR FSH complex

Sanders, J., Chirgadze, D.Y., Sanders, P., Baker, S., Sullivan, A., Bhardwaja, A., Bolton, J., Reeve, M., Nakatake, N., Evans, M., Richards, T., Powell, M., Miguel, R.N., Blundell, T.L., Furmaniak, J., Smith, B.R. Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody Thyroid. 2007 May;17(5):395-410. PDB: 3G04 | Fan QR, Hendrickson WA Structure of human follicle-stimulating hormone in complex with its receptor Nature. 2005 Jan 20;433(7023):203-4 PDB: 1XWD | |
G-Proteins (Gi, Gs)
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Sunahara, R. K., Tesmer, J. J., Gilman, A. G., Sprang, S. R. Crystal structure of the adenylyl cyclase activator Gsalpha Science 278 pp. 1943 (1997) PDB: 1AZT | Wall, M. A., Coleman, D. E., Lee, E., Iniguez-Lluhi, J. A., Posner, B. A., Gilman, A. G., Sprang, S. R. The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2 Cell 83 pp. 1047 (1995) PDB: 1GP2 | Wall, M. A., Coleman, D. E., Lee, E., Iniguez-Lluhi, J. A., Posner, B. A., Gilman, A. G., Sprang, S. R. The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2 Cell 83 pp. 1047 (1995) PDB: 1GG2 | |